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Adip14NZB/BlNJ
QTL Variant Detail
Summary
QTL variant: Adip14NZB/BlNJ
Name: adiposity 14; NZB/BlNJ
MGI ID: MGI:3614987
QTL: Adip14  Location: unknown  Genetic Position: Chr9, Syntenic
Variant
origin
Strain of Specimen:  NZB/BlNJ
Variant
description
Allele Type:    QTL
Mutation:    Undefined
    Heterozygous animals exhibit increased retroperitoneal fat pad weight compared to homozygotes. (J:103841)
Inheritance:    Other (see notes)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Notes
Adip14 exhibits overdominance.

Mapping and Phenotype information for this QTL, its variants and associated markers

J:103841

Linkage analysis was performed on 513 animals from a (SM/J x NZB/BlNJ)F2 intercross to identify QTL affecting obesity traits. Animals were placed on an atherogenic diet for 16 weeks before phenotyping. Parental strain SM/J exhibits smaller body size but higher adiposity compared to parental strain NZB/BlNJ.

Adip14 maps to 60 cM on mouse Chromosome 9 near D9Mit15 (LOD=3.9) with a 95% confidence interval spanning 48 cM - 60 cM. Adip14 exhibits overdominance as heterozygous animals exhibit increased retroperitoneal fat pad weights compared to SM/J or NZB/BlNJ homozygotes. Previously identified adiposity QTL Adip5 (42 cM) maps near the Adip14 interval.

References
Original:  J:103841 Stylianou IM, et al., Quantitative trait locus analysis for obesity reveals multiple networks of interacting loci. Mamm Genome. 2006 Jan;17(1):22-36
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
05/14/2024
MGI 6.23
The Jackson Laboratory