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Adip13NZB/BlNJ
QTL Variant Detail
Summary
QTL variant: Adip13NZB/BlNJ
Name: adiposity 13; NZB/BlNJ
MGI ID: MGI:3614982
QTL: Adip13  Location: unknown  Genetic Position: Chr5, cM position of peak correlated region/allele: 26.89 cM
QTL Note: genome coordinates based on the marker associated with the peak LOD score
Variant
origin
Strain of Specimen:  NZB/BlNJ
Variant
description
Allele Type:    QTL
Inheritance:    Other (see notes)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Notes
Adip13 exhibits additive inheritance.

Mapping and Phenotype information for this QTL, its variants and associated markers

J:103841

Linkage analysis was performed on 513 animals from a (SM/J x NZB/BlNJ)F2 intercross to identify QTL affecting obesity traits. Animals were placed on an atherogenic diet for 16 weeks before phenotyping. Parental strain SM/J exhibits smaller body size but higher adiposity compared to parental strain NZB/BlNJ.

On mouse Chromosome 5, Adip13 maps to 26 cM near D5Mit81 (LOD=2.9) with a 95% confidence interval spanning 8 cM - 44 cM. NZB/BlNJ-derived alleles at Adip13 confer increased gonadal fat pad weight with an additive mode of inheritance. Nobq1 (28 cM) andObq11 (10 cM) are previously identified obesity QTL mapping near the Adip13 interval.

Obwq2 maps to 44 cM near D5Mit204 (LOD=3.7) with the 95% confidence interval spanning approximately 16 cM - 66 cM.NZB/BlNJ-derived alleles at Obwq2 confer increased body weight and inguinal and gonadal fat pad weights with a dominant mode of inheritance. Previously identified QTL mapping near Obwq2 are Nobq1 (28 cM) and Obq11 (10 cM).

References
Original:  J:103841 Stylianou IM, et al., Quantitative trait locus analysis for obesity reveals multiple networks of interacting loci. Mamm Genome. 2006 Jan;17(1):22-36
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
07/05/2024
MGI 6.24
The Jackson Laboratory