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Bwtq8NZB/BlNJ
QTL Variant Detail
Summary
QTL variant: Bwtq8NZB/BlNJ
Name: body weight QTL 8; NZB/BlNJ
MGI ID: MGI:3614869
QTL: Bwtq8  Location: unknown  Genetic Position: Chr2, cM position of peak correlated region/allele: 42.74 cM
QTL Note: genome coordinates based on the marker associated with the peak LOD score
Variant
origin
Strain of Specimen:  NZB/BlNJ
Variant
description
Allele Type:    QTL
Mutation:    Undefined
    This allele confers increased lean body weight compared to SM/J. (J:103841)
Inheritance:    Other (see notes)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 1 anatomical structure(s)
Notes
Bwtq8 exhibits additive inheritance.

Mapping and Phenotype information for this QTL, its variants and associated markers

J:103841

Linkage analysis was performed on 513 animals from a (SM/J x NZB/BlNJ)F2 intercross to identify QTL affecting obesity traits. Animals were placed on an atherogenic diet for 16 weeks before phenotyping. Parental strain SM/J exhibits smaller body size but higher adiposity compared to parental strain NZB/BlNJ.

On mouse Chromosome 2, Adip10 maps to 2 cM near D2Mit1 (LOD=3.5) with a 95% confidence interval spanning approximately 0 cM - 34 cM. SM/J-derived alleles at Adip10 confer increased inguinal and retroperitoneal fat pad weights with an additive mode of inheritance. Previously identified obesity QTL Obq3 (53 cM), Mob6 (49.6 cM), and Fob1 (45 cM) maps near the Adip10 interval.

Bwtq8 maps to 42 cM near D2Mit92 (LOD=4) with a 95% confidence interval spanning approximately 34 cM - 78 cM. NZB/BlNJ-derived alleles at Bwtq8 confer increased lean body weight with and additive mode of inheritance. Bwq5 (81.7 cM), Nidd5 (34.5 cM), and Pbwg1 (32.8 cM) are previously identified body weight QTL located near Bwtq8.

References
Original:  J:103841 Stylianou IM, et al., Quantitative trait locus analysis for obesity reveals multiple networks of interacting loci. Mamm Genome. 2006 Jan;17(1):22-36
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
05/07/2024
MGI 6.23
The Jackson Laboratory