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QTL Variant Detail
QTL variant: Obwq1SM/J
Name: obesity and body weight QTL 1; SM/J
MGI ID: MGI:3614849
QTL: Obwq1  Location: unknown  Genetic Position: Chr1, cM position of peak correlated region/allele: 50.93 cM
QTL Note: genome coordinates based on the marker associated with the peak LOD score
Strain of Specimen:  SM/J
Allele Type:    QTL
Inheritance:    Recessive
View phenotypes and curated references for all genotypes (concatenated display).
In Structures Affected by this Mutation: 3 anatomical structures

Mapping and Phenotype information for this QTL, its variants and associated markers


Linkage analysis was performed on 513 animals from a (SM/J x NZB/BlNJ)F2 intercross to identify QTL affecting obesity traits. Animals were placed on an atherogenic diet for 16 weeks before phenotyping. Parental strain SM/J exhibits smaller body size but higher adiposity compared to parental strain NZB/BlNJ.

Obwq1 maps to 62 cM on mouse Chromosome 1 near D1Mit87 (LOD=4.3) with the 95% confidence interval spanning approximately 24 cM - 64 cM. NZB/BlNJ-derived alleles at Obwq1 confer increased body weightand mesenteric fat pad weight with a dominant mode of inheritance. Previously identified obesity QTL mapping near Obwq1 are Fatq1 (62 cM) and Obq8 (69.1 cM).

Original:  J:103841 Stylianou IM, et al., Quantitative trait locus analysis for obesity reveals multiple networks of interacting loci. Mamm Genome. 2006 Jan;17(1):22-36
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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MGI 6.22
The Jackson Laboratory