About   Help   FAQ
QTL Variant Detail
QTL variant: Rmp6C57BL/6NCr
Name: resistance to mousepox 6; C57BL/6NCr
MGI ID: MGI:3614845
QTL: Rmp6  Location: unknown  Genetic Position: Chr17, Syntenic
Strain of Specimen:  C57BL/6NCr
Allele Type:    QTL
Mutation:    Undefined
    This allele confers resistance to ectromelia virus compared to DBA/2NCr. (J:3240)
View phenotypes and curated references for all genotypes (concatenated display).

Mapping and Phenotype information for this QTL, its variants and associated markers


Confirmation of linkage between H2-D and Rmp3 on mouse Chromosome 17 was established. (C57BL/6NCr x DBA/2NCr)F1 female mice were backcrossed to DBA/2NCr male mice deriving an N2 founder male of the genotype H2-Db Rmp3r with the C57BL/6 allele H-2Dbbeing a marker for the Rmp3 resistant phenotype. Data derived from the concordant passage of these two genes through seven generations of backcrosses to DBA/2NCr suggest a recombination frequency of 0.2 to 0.3 between H2-D and Rmp3.

10.8.2015 Curator Note: Rmp3 was orginally mapped using a (C57BL/6J x DBA/2J)F1 x DBA/2J backcross in 1991 in J:11032. A second cross in the same study identified QTL Rmp6 using

a (C57BL/6NCr x DBA/2NCr)F1 x DBA/NCr backcross population. We have equated the map study here as confirming Rmp6.


Linkage to mousepox susceptibility was mapped in 101 male animals from a (C57BL/6J x DBA/2J)F1 x DBA/2J backcross inoculated with 105 PFU of mouse ectromelia virus. Inbred strain DBA/2J is highly susceptible to infection with ectromelia virus whereas inbred strain C57BL/6J is resistant. Rmp2 (resistance to mousepox 2) and Rmp3 (resistance to mousepox 3) were identified near Hc (23.5 cM) on mouse Chromosome 2 and near H2-D (19 cM) on mouse Chromosome 17, respectively. Homozygosity for DBA/2J-derived alleles at Rmp2 and Rmp3 is associated with susceptibility to ectromelia virus infection and increased post-infection mortality.

10.8.2015 Curator Note: When previoulsy identified QTL are cited as confirmed or verified within the same study, using a different cross then that initially used, we have created a new QTL. We consider each distinct cross to be a separate mapping experiment. We have named the QTL identified here using the (C57BL/6NCr x DBA/2NCr)F1 x DBA/NCr backcross as Rmp5 and Rmp6 repectively.

Analysis of 66 males animals from a (C57BL/6NCr x DBA/2NCr)F1 x DBA/NCr backcross had similar results. When the experiment was repeated on gonadectomized and sham-operated male backcross animals, Rmp5 and Rmp6 were shown to confer additional protection against ectromelia virus in sham-operated animals. This finding indicates that Rmp5 and Rmp6 exhibit responsiveness to hormonal sexfactors. The complement component C3 (34.3 cM) maps near Rmp6. C3 is androgen-responsive and may be a possible candidate gene.

Original:  J:3240 Brownstein DG, et al., Serial backcross analysis of genetic resistance to mousepox, using marker loci for Rmp-2 and Rmp-3. J Virol. 1992 Dec;66(12):7073-9
All:  2 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support.
last database update
MGI 6.23
The Jackson Laboratory