About   Help   FAQ
Rmp1C57BL/6J
QTL Variant Detail
Summary
QTL variant: Rmp1C57BL/6J
Name: resistance to mousepox; C57BL/6J
MGI ID: MGI:3613792
QTL: Rmp1  Location: unknown  Genetic Position: Chr6, Syntenic
Variant
origin
Strain of Specimen:  C57BL/6J
Variant
description
Allele Type:    QTL
Inheritance:    Dominant
Notes

Mapping and Phenotype information for this QTL, its variants and associated markers

J:28150

Rmp1 (resistance to mousepox 1) is a locus on distal mouse Chromosome 6 near Prh1 (63.6 cM; formerly Prp) conferring susceptibility to ectromelia virus. Rmp1 was provisionally mapped in a series of 25 recombinant inbred strains derived from C57BL/6J and DBA/2J. Inbred strain DBA/2J is highly susceptible to infection with ectromelia virus whereas inbred strain C57BL/6J is resistant. 101 male animals from a (C57BL/6J x DBA/2J)F1 x DBA/2J backcross were challenged with 105 PFU of Moscow strain ectromelia virus, and of these animals 18 died and 83 survived. All 18 animals that died were homozygous for DBA/2J-derived alleles at Prh1. The experiment was repeated in a population of 42 castrated male (C57BL/6J x DBA/2J)F1 x DBA/2J animals with similar results.All susceptible animals were homozygous for DBA/2J-derived alleles on chromosome 6 from 51 cM - 63 cM, a region that includes the Klrb1c (62.1 cM) locus. Both experiments support the hypothesis that a locus associated with ecromelia virus susceptibility named Rmp1 is located near Prh1 at 63.6 cM. A previously identified cytomegalovirus susceptibility locus named Klra8 (62.69 cM; formerly Cmv1) maps near Rmp1.

References
Original:  J:28150 Delano ML, et al., Innate resistance to lethal mousepox is genetically linked to the NK gene complex on chromosome 6 and correlates with early restriction of virus replication by cells with an NK phenotype. J Virol. 1995 Sep;69(9):5875-7
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support.
last database update
03/19/2024
MGI 6.23
The Jackson Laboratory