Cxcr6^tm1Litt
Targeted Allele Detail

Summary

• Symbol: Cxcr6^tm1Litt
• Name: C-X-C motif chemokine receptor 6; targeted mutation 1, Daniel Littman
• MGI ID: MGI:3613526
• Synonyms: Bonzo^-, Bz^-, cxcr6^gfp, Cxcr6^tm1Unu
• Gene: Cxcr6 Location: Chr9:123635542-123640819 bp, + strand Genetic Position: Chr9, 74.57 cM, cytoband F
• Alliance: Cxcr6^tm1Litt page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:104242
• Parent Cell Line: E14 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutations: Insertion, Intragenic deletion
• Mutation details: The coding sequence was replaced with an EGFP. RT-PCR failed to detect transcript in mutants. Strong GFP expression was detected in spleen and lymphoid nodes. (J:104242, J:131925)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 2 strains available Cell Lines: 0 lines available
• Carrying any Cxcr6 Mutation: 30 strains or lines available

References

• Original: J:104242 Unutmaz D, et al., The primate lentiviral receptor Bonzo/STRL33 is coordinately regulated with CCR5 and its expression pattern is conserved between human and mouse. J Immunol. 2000 Sep 15;165(6):3284-92
• All: 61 reference(s)