Apoe^{tm2(APOE_i2)Sfu}
Targeted Allele Detail

Summary

• Symbol: Apoe^{tm2(APOE_i2)Sfu}
• Name: apolipoprotein E; targeted mutation 2, Shinobu C Fujita
• MGI ID: MGI:3613513
• Synonyms: 2/2
• Gene: Apoe Location: Chr7:19430034-19433113 bp, - strand Genetic Position: Chr7, 9.94 cM
• Alliance: Apoe^{tm2(APOE_i2)Sfu} page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:104859
• Parent Cell Line: E14TG2a (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Humanized sequence, Inserted expressed sequence)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A portion of the endogenous locus, spanning from within exon 2 through most of exon 4, was replaced by the human cDNA encoding APOE isoform 2. Mouse protein was not detected in Western blot of mutants. Human protein was shown to be robustly expressed. (J:104859)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 2 strains available Cell Lines: 0 lines available
• Carrying any Apoe Mutation: 145 strains or lines available

References

• Original: J:104859 Mori T, et al., Increased vulnerability to focal ischemic brain injury in human apolipoprotein E4 knock-in mice. J Neuropathol Exp Neurol. 2003 Mar;62(3):280-91
• All: 3 reference(s)