Tgfbr1^tm1Spo
Targeted Allele Detail

Summary

• Symbol: Tgfbr1^tm1Spo
• Name: transforming growth factor, beta receptor I; targeted mutation 1, S Paul Oh
• MGI ID: MGI:3613461
• Synonyms: Alk5^lacZ
• Gene: Tgfbr1 Location: Chr4:47353222-47414926 bp, + strand Genetic Position: Chr4, 26.02 cM
• Alliance: Tgfbr1^tm1Spo page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:104918
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutation: Insertion
• Mutation details: A lacZ-neo and a copy of exon IV were inserted downstream of exon IV upon homologous recombination originally intended to replace exon III with the lacZ-neo. Exon 3 encodes the transmembrane domain. X-gal staining revealed the expression of lacZ in a variety of tissues and organs during embryonic development, and was especially strong in connective tissues surrounding developing skeletons. (J:104918)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Tgfbr1 Mutation: 36 strains or lines available

References

• Original: J:104918 Seki T, et al., Nonoverlapping expression patterns of ALK1 and ALK5 reveal distinct roles of each receptor in vascular development. Lab Invest. 2006 Feb;86(2):116-29
• All: 2 reference(s)