Tnfsf12^tm1Ash
Targeted Allele Detail

Summary

• Symbol: Tnfsf12^tm1Ash
• Name: tumor necrosis factor (ligand) superfamily, member 12; targeted mutation 1, Avi Ashikenazi
• MGI ID: MGI:3613442
• Synonyms: TWEAK^-, TWEAK-KO
• Gene: Tnfsf12 Location: Chr11:69577076-69586675 bp, - strand Genetic Position: Chr11, 42.86 cM, cytoband B4
• Alliance: Tnfsf12^tm1Ash page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:104801
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A targeting vector was designed to replace 2.5 kb of the locus, encompassing the first exon and all five downstream exons, with a PGK-neo cassette. Quantitative RT-PCR failed to detect transcript in mutants. (J:104801)

Expression

In Structures Affected by this Mutation:

3 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Tnfsf12 Mutation: 104 strains or lines available

References

• Original: J:104801 Maecker H, et al., TWEAK attenuates the transition from innate to adaptive immunity. Cell. 2005 Dec 2;123(5):931-44
• All: 7 reference(s)