Cyx^C57BL/6J
QTL Variant Detail

Summary

• QTL variant: Cyx^C57BL/6J
• Name: cycloheximide tasting; C57BL/6J
• MGI ID: MGI:3612099
• QTL: Cyx Location: Chr6:132546805-132549364 bp Genetic Position: Chr6, Syntenic

Variant origin

• Strain of Specimen: C57BL/6J

Variant description

• Allele Type: QTL

Notes

Candidate Genes

J:4423

Qui, Rua, Cyx are linked to Prh1. Using 20 BXD and 7 CXB RI strains, no recombinants were detected between Qui and Prh1 (data not shown). Prp was orginally assigned to Chromosome 8, but later the assignment was corrected to Chromosome 6.

Mapping and Phenotype information for this QTL, its variants and associated markers

J:12143

In 20 BXD RI strains and 7 CXB RI strains the strain distribution pattern for Prh1 and Qui was identical (95% confidence interval gives a genetic distance of 0-3.95 cM). Genes Rua and Cyx also followed this pattern. All four genes are very closely linked or may be identical.

J:9722

The strain distribution pattern of cyclohexamide tasting, Cyx, showed strong similiarites to the strain distibution patterns of Rua and Qui in 21 BXD (C=C57BL/6J; D=DBA/2) recombinant inbred (RI) strains. This suggests that Cyx is closely linked to Rua and Qui on mouse Chromosome 6 at approximately 50 cM.

References

• Original: J:9722 Lush IE, et al., The genetics of tasting in mice. V. Glycine and cycloheximide. Genet Res. 1988 Dec;52(3):207-12
• All: 1 reference(s)