Lat^tm1Bpay
Targeted Allele Detail

Summary

• Symbol: Lat^tm1Bpay
• Name: linker for activation of T cells; targeted mutation 1, B Payrastre
• MGI ID: MGI:3611936
• Synonyms: LAT^-
• Gene: Lat Location: Chr7:125962996-125968742 bp, - strand Genetic Position: Chr7, 69.01 cM
• Alliance: Lat^tm1Bpay page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:103904
• Parent Cell Line: CK35 (ES Cell)
• Strain of Origin: 129S2/SvPas

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A loxP-flanked neomycin resistance gene replaced the locus. Crossing with mice expressing cre in the germline removed the neo cassette. (J:103904)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Lat Mutation: 9 strains or lines available

References

• Original: J:103904 Trumel C, et al., Platelet aggregation induced by the C-terminal peptide of thrombospondin-1 requires the docking protein LAT but is largely independent of alphaIIb/beta3. J Thromb Haemost. 2003 Feb;1(2):320-9
• All: 1 reference(s)