Pou4f1^tm1Dsl
Targeted Allele Detail

Summary

• Symbol: Pou4f1^tm1Dsl
• Name: POU domain, class 4, transcription factor 1; targeted mutation 1, David S Latchman
• MGI ID: MGI:3611849
• Synonyms: 118
• Gene: Pou4f1 Location: Chr14:104699112-104705435 bp, - strand Genetic Position: Chr14, 54.21 cM, cytoband E1-E3
• Alliance: Pou4f1^tm1Dsl page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:103665
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129X1/SvJ

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Disruption caused by insertion of vector
• Mutation details: The first 50 bp of exon 1 were replaced with a TK-neomycin cassette. The promoter for the short form of the protein was left intact. RT-PCR analysis demonstrated the presence of a transcript capable of encoding the short form of the protein. No transcript corresponding to the long form of the protein was detected. (J:103665)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Pou4f1 Mutation: 13 strains or lines available

References

• Original: J:103665 Faulkes DJ, et al., Distinct domains of Brn-3a regulate apoptosis and neurite outgrowth in vivo. Neuroreport. 2004 Jun 28;15(9):1421-5
• All: 1 reference(s)