Sorbs3^tm1Kmor
Targeted Allele Detail

Summary

• Symbol: Sorbs3^tm1Kmor
• Name: sorbin and SH3 domain containing 3; targeted mutation 1, Ken-ichirou Morohashi
• MGI ID: MGI:3611214
• Synonyms: Vinexin gamma^-
• Gene: Sorbs3 Location: Chr14:70417917-70449438 bp, - strand Genetic Position: Chr14, 36.27 cM
• Alliance: Sorbs3^tm1Kmor page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:102860
• Parent Cell Line: AB1 (ES Cell)
• Strain of Origin: 129S7/SvEvBrd-Hprt1⁺

Mutation description

• Allele Type: Targeted (Modified isoform(s))
• Mutations: Insertion, Intragenic deletion
• Mutation details: The gamma-form specific first exon was deleted along with the upstream region upon the insertion of a PGK-neo-pA cassette. Fetal gonads were analyzed by western blot to confirm absence of the gamma and alpha isoforms. The beta isoform is still expressed. (J:102860)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Sorbs3 Mutation: 32 strains or lines available

References

• Original: J:102860 Matsuyama M, et al., A novel isoform of Vinexin, Vinexin gamma, regulates Sox9 gene expression through activation of MAPK cascade in mouse fetal gonad. Genes Cells. 2005 May;10(5):421-34
• All: 1 reference(s)