Septin6^tm1Nosa
Targeted Allele Detail

Summary

• Symbol: Septin6^tm1Nosa
• Name: septin 6; targeted mutation 1, Tetsuya Nosaka
• MGI ID: MGI:3611071
• Synonyms: Sept6^-
• Gene: Septin6 Location: ChrX:36174925-36253711 bp, - strand Genetic Position: ChrX, 21.32 cM, cytoband A2
• Alliance: Septin6^tm1Nosa page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:103760
• Parent Cell Line: E14.1 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A targeting vector was designed to replace part of 3, including the second ATG which starts from 6 bp downstream of the P-loop motif within the GTP-binding domain. Western blot failed to detect protein in mutant brain. (J:103760)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Septin6 Mutation: 8 strains or lines available

References

• Original: J:103760 Ono R, et al., Disruption of Sept6, a fusion partner gene of MLL, does not affect ontogeny, leukemogenesis induced by MLL-SEPT6, or phenotype induced by the loss of Sept4. Mol Cell Biol. 2005 Dec;25(24):10965-78
• All: 2 reference(s)