Casp2^tm1Vaux
Targeted Allele Detail

Summary

• Symbol: Casp2^tm1Vaux
• Name: caspase 2; targeted mutation 1, David L Vaux
• MGI ID: MGI:3609949
• Synonyms: Casp2^-
• Gene: Casp2 Location: Chr6:42241942-42259442 bp, + strand Genetic Position: Chr6, 20.54 cM
• Alliance: Casp2^tm1Vaux page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:103480
• Parent Cell Line: W9.5/W95 (ES Cell)
• Strain of Origin: 129S1/Sv-Oca2⁺ Tyr⁺ Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A 1.65 kb genomic fragment containing sequences that encode part of the active site of the protein and other essential regions was replaced via homologous recombination with a neomycin resistance cassette in forward orientation. (J:103480)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Casp2 Mutation: 22 strains or lines available

References

• Original: J:103480 O'Reilly LA, et al., Caspase-2 is not required for thymocyte or neuronal apoptosis even though cleavage of caspase-2 is dependent on both Apaf-1 and caspase-9. Cell Death Differ. 2002 Aug;9(8):832-41
• All: 16 reference(s)