About   Help   FAQ
QTL Variant Detail
QTL variant: Anth2CBA/J
Name: resistance to Bacillus anthracis 2; CBA/J
MGI ID: MGI:3609202
QTL: Anth2  Location: unknown  Genetic Position: Chr2, Syntenic
Strain of Specimen:  CBA/J
Allele Type:    QTL
Mutation:    Undefined
    This allele confers resistance to the Sterne strain of Bacillus anthracis compared to A/J. (J:9501)
View phenotypes and curated references for all genotypes (concatenated display).

Mapping and Phenotype information for this QTL, its variants and associated markers


Anth2 is a previously identified QTL for resistance/susceptibility to infection with the Sterne strain of Bacillus anthracis. Anth2 is located on mouse Chromosome 2 and shows association with the Hc locus at 23.5 cM. Hc appears to be an attractive candidate gene for Anth2 as resistant inbred mouse strains CBA/J and BALB/cJ carry functional Hc genes while the susceptible inbred mouse strain A/J carries deficient Hc genes. The following experiments support the candidacy of Hc as the gene responsible for Anth2.

The association of Sterne resistance/susceptibility was evaluated in 46 (A/J x CBA/J)F1 x A/J backcross animals and 48 (A/J x CBA/J)F1 x CBA/J backcross animal. None of the (A/J x CBA/J)F1 x CBA/J backcross animals died after infection with 105 units of Sterne B.anthracis while 39% of (A/J x CBA/J)F1 x A/J backcross animals succumbed to infection. All of the animals that died displayed 1% Hc activity while all surviving animals displayed between 11%-100% Hc activity. (%Hc activity was measured relative to the Hc activity in resistant parental strain CBA/J.) Interestingly, surviving backcross animals with pre-infection Hc activity levels between 15%-33% showed an increase to 68%-95% post-infection.

Sterne resistance/susceptibility was also evaluated in a population of 46 (A/J x CBA/J)F2 animals. Only 5 (11%) F2 animals died after infection with 10<5 units of Sterne B.anthracis. Again, all of the F2 animals that died from Sterne infection were negative for Hc activity while 98% of the surviving F2 animals were positive for Hc activity.

A group of 7 different AXL (A=A/J; L=C57L/J) recombinant inbred (RI) strain and 7 different BXD (B=C57BL/6J; D=DBA/J) RI strains were infected with 105 units of Sterne B.anthracis and evaluated for survival. 70%-100% of animals from Hc negative RI strains died after Sterne infection compared to 1%-14% of animals from Hc positive RI strains.

Original:  J:9501 Welkos SL, et al., Pathogenesis and genetic control of resistance to the Sterne strain of Bacillus anthracis. Microb Pathog. 1988 Jan;4(1):53-69
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Copyright, and Privacy Statement
Send questions and comments to User Support.
last database update
MGI 6.22
The Jackson Laboratory