Msmr1^SL/Kh
QTL Variant Detail

Summary

• QTL variant: Msmr1^SL/Kh
• Name: MSM lymphoma resistance 1; SL/Kh
• MGI ID: MGI:3609167
• QTL: Msmr1 Location: unknown Genetic Position: Chr17, Syntenic

Variant origin

• Strain of Specimen: SL/KhStmRbrc

Variant description

• Allele Type: QTL
• Mutation: Undefined
• This locus confers lymphoma susceptibility compared to MSM/Ms. (J:34941)
• Inheritance: Recessive

Notes

Homozygosity for SL/Kh-derived alleles at both Msmr1 and Msmr2 is associated with high incidence of acute pre-B lymphoma.

Mapping and Phenotype information for this QTL, its variants and associated markers

J:34941

All the chromosomes of progeny from a (MSM/Ms x SL/Kh)F1 x SL/Kh backcross were scanned for linkage of lymphoma susceptibility with 79 polymorphic microsatellite loci spaced 15 cM - 30 cM apart. Authors found a significant linkage disequilibrium in the proximal segment of mouse Chromosome 17, between D17Mit44 (11 cM) and D17Mit150 (33.3 cM). These data map Msmr1 between D17Mit44 and D17Mit150 on mouse Chromosome 17. The MSM/Ms-derived allele at Msmr1 is associated with dominant lymphoma resistance whereas the SL/Kh-derived allele is associated with susceptibility. Several host resistance loci map near Msmr1, such as Rfv1 (19.5 cM), Rgv1 (19.5 cM), Rmv1 (19.5 M), Rrv1 (19.5 cM), Rrsv (19.5 cM), and H2-Bf (18.85 cM).

References

• Original: J:34941 Pataer A, et al., Two dominant host resistance genes to pre-B lymphoma in wild-derived inbred mouse strain MSM/Ms. Cancer Res. 1996 Aug 15;56(16):3716-20
• All: 1 reference(s)