Lyr2^SL/Ni
QTL Variant Detail

Summary

• QTL variant: Lyr2^SL/Ni
• Name: lymphoma resistance 2; SL/Ni
• MGI ID: MGI:3609038
• QTL: Lyr2 Location: Chr4:14010457-63283678 bp Genetic Position: Chr4, Syntenic

Variant origin

• Strain of Specimen: SL/Ni

Variant description

• Allele Type: QTL
• Mutation: Undefined
• This allele confers resistance to spontaneous development of B lymphomas compared to SL/Kh. (J:32436)
• Inheritance: Recessive

Notes

Mapping and Phenotype information for this QTL, its variants and associated markers

J:32436

SL/Kh mice are resistant to spontaneous B lymphoma, whereas SL/Ni mice are susceptible. In order to genetically map the locus or loci responsible for the resistant phenotype, various combinations of backcrosses were established using SL/Kh and SL/Ni miceand then genotyping the backcross offspring for 40 microsatellite marker loci covering 60% of the genome. Chi-square analysis showed that the resistant/susceptible phenotype segregated significantly with mouse Chromosome 4 marker D4Mit39. Thus a locus forthis recessive phenotype (Lyr2) maps with mouse Chromosome 4 to a region approximately 20 cMs from the centromere. The SL/Ni-derived allele confers resistance to spontaneous B lymphomas.

Genetic markers flanking the Lyr2 interval are D4Mit18 (5.2 cM) andD4Mit17 (31 cM). The Lyr2 region includes Cd72 (22.5 cM, formerly Lyb2) and Mup1 (27.8 cM). A previously mapped lymphoma resistance locus named Foc1 (31 cM) overlaps with Lyr2. The lymphoma resistance locus Lyrb (40 cM) maps distal to Lyr2.

References

• Original: J:32436 Shisa H, et al., Genetic and epigenetic resistance of SL/Ni mice to lymphomas. Jpn J Cancer Res. 1996 Mar;87(3):258-62
• All: 1 reference(s)