Cpb2^tm1Jcmm
Targeted Allele Detail

Summary

• Symbol: Cpb2^tm1Jcmm
• Name: carboxypeptidase B2; targeted mutation 1, J C M Meijers
• MGI ID: MGI:3608921
• Synonyms: TAFI^-
• Gene: Cpb2 Location: Chr14:75479727-75520995 bp, + strand Genetic Position: Chr14, 39.73 cM, cytoband D2
• Alliance: Cpb2^tm1Jcmm page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:102729
• Parent Cell Line: E14 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A neomycin resistance gene in opposite orietation replaced part of intron 1, exon 2 and part of intron 2. The absence of mRNA in livers was confirmed by Northern blot. Western blot failed to detect protein in mutants. (J:102729)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Cpb2 Mutation: 30 strains or lines available

References

• Original: J:102729 te Velde EA, et al., Impaired healing of cutaneous wounds and colonic anastomoses in mice lacking thrombin-activatable fibrinolysis inhibitor. J Thromb Haemost. 2003 Oct;1(10):2087-96
• All: 9 reference(s)