About   Help   FAQ
Aem1C57BL/6
QTL Variant Detail
Summary
QTL variant: Aem1C57BL/6
Name: antierythrocyte autoantibody modifier 1; C57BL/6
MGI ID: MGI:3608856
QTL: Aem1  Location: unknown  Genetic Position: Chr4, Syntenic
Variant
origin
Strain of Specimen:  C57BL/6
Variant
description
Allele Type:    QTL
Mutation:    Undefined
    This allele confers resistance to anti-erythrocyte autoantibody production compared to NZB. (J:7191)
Inheritance:    Dominant
Phenotypes
Loading...
View phenotypes and curated references for all genotypes (concatenated display).
Notes

Mapping and Phenotype information for this QTL, its variants and associated markers

J:7191

A population of (C57BL/6 x NZB)F1 x NZB backcross animals were analyzed for linkage to anti-erythrocyte autoantibody (AEA) production. Parental strain NZB exhibits AEA production starting at 4 months of age whereas parental strain C57BL/6 and F1 animals do not exhibit AEA production up to 13 months of age. A locus named Aem1 (anti-erythrocyte autoantibody modifier 1) mapped to mouse Chromosome 4 upstream of Mup1 (27.8 cM). C57BL/6J-derived alleles at Aem1 confer inhibition of AEA production with dominantinheritance. A potential candidate gene for Aem1 is Cd72 (22.5 cM, formerly Lyb2) but parental strain C57BL/6 and NZB were found to share the same allele at Cd72.

References
Original:  J:7191 Ozaki S, et al., Genetic regulation of erythrocyte autoantibody production in New Zealand black mice. Immunogenetics. 1983;18(3):241-54
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support.
last database update
03/19/2024
MGI 6.23
The Jackson Laboratory