P2rx7^tm1Ipch
Targeted Allele Detail

Summary

• Symbol: P2rx7^tm1Ipch
• Name: purinergic receptor P2X, ligand-gated ion channel, 7; targeted mutation 1, Iain P Chessell
• MGI ID: MGI:3606250
• Synonyms: Glaxo P2X7R^-, P2rx7^tm1Blo, P2X7^-, P2X7R^-
• Gene: P2rx7 Location: Chr5:122781974-122829495 bp, + strand Genetic Position: Chr5, 62.5 cM, cytoband F
• Alliance: P2rx7^tm1Ipch page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:101945
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Insertion
• Mutation details: The targeting event results in the disruption of exon 1 by insertion of a LacZ gene (in-frame with the initiation codon) and neomycin selection cassette without deletion of any of the endogenous gene sequence. T cells in this strain retain high levels of P2X7 activity. The 13a isoform is expressed in these mice but no expression of the 13b or 13c isoforms is detected. (J:97422, J:101945, J:149750, J:194518)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any P2rx7 Mutation: 52 strains or lines available

References

• Original: J:97422 Sikora A, et al., Cutting edge: purinergic signaling regulates radical-mediated bacterial killing mechanisms in macrophages through a P2X7-independent mechanism. J Immunol. 1999 Jul 15;163(2):558-61
• All: 35 reference(s)