Icam1^tm1Alb
Targeted Allele Detail

Summary

• Symbol: Icam1^tm1Alb
• Name: intercellular adhesion molecule 1; targeted mutation 1, Arthur L Beaudet
• MGI ID: MGI:3605161
• Synonyms: ICAM-1^-, ICAM-1^null
• Gene: Icam1 Location: Chr9:20927281-20940113 bp, + strand Genetic Position: Chr9, 7.69 cM
• Alliance: Icam1^tm1Alb page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:100242
• Parent Cell Line: AB2.1 (ES Cell)
• Strain of Origin: 129S7/SvEvBrd-Hprt1^b-m2

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: The entire coding region was deleted, from the BamHI site 5' of exon 1 to the SalI site 3' of the poly(A) site in exon 7, and replaced by a puromycin resistance cassette transcribed in the opposite direction. (J:100242, J:142629)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Icam1 Mutation: 24 strains or lines available

References

• Original: J:100242 Dunne JL, et al., Mac-1, but not LFA-1, uses intercellular adhesion molecule-1 to mediate slow leukocyte rolling in TNF-alpha-induced inflammation. J Immunol. 2003 Dec 1;171(11):6105-11
• All: 18 reference(s)