Dusp9^tm1Skey
Targeted Allele Detail

Summary

• Symbol: Dusp9^tm1Skey
• Name: dual specificity phosphatase 9; targeted mutation 1, Stephen M Keyse
• MGI ID: MGI:3604672
• Synonyms: DUSP9^-
• Gene: Dusp9 Location: ChrX:72683025-72687120 bp, + strand Genetic Position: ChrX, 37.37 cM, cytoband B
• Alliance: Dusp9^tm1Skey page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:101370
• Parent Cell Line: GK129 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exons 2 and 3 were replaced with the En2A-IRESbetageoPA cassette. The replaced sequence encodes amino acids 194 to 452, encompassing the entire catalytic domain of the protein, including the protein tyrosine phosphatase active-site motif HCXXGXXRS. Western blot failed to detect protein in mutant ES cells. (J:101370)

Expression

In Mice Carrying this Mutation:	101 assay results
In Structures Affected by this Mutation:	1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Dusp9 Mutation: 26 strains or lines available

References

• Original: J:101370 Christie GR, et al., The dual-specificity protein phosphatase DUSP9/MKP-4 is essential for placental function but is not required for normal embryonic development. Mol Cell Biol. 2005 Sep;25(18):8323-33
• All: 1 reference(s)