Cradd^tm1Mak
Targeted Allele Detail

Summary

• Symbol: Cradd^tm1Mak
• Name: CASP2 and RIPK1 domain containing adaptor with death domain; targeted mutation 1, Tak W Mak
• MGI ID: MGI:3604302
• Synonyms: RAIDD^-
• Gene: Cradd Location: Chr10:95010608-95159995 bp, - strand Genetic Position: Chr10, 49.26 cM
• Alliance: Cradd^tm1Mak page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:101402
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exon 1 was replaced with a neomycin resistance gene. Northern blot confirmed the lack of RNA expression in mutant liver samples. (J:101402)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Cradd Mutation: 106 strains or lines available

References

• Original: J:101402 Berube C, et al., Apoptosis caused by p53-induced protein with death domain (PIDD) depends on the death adapter protein RAIDD. Proc Natl Acad Sci U S A. 2005 Oct 4;102(40):14314-20
• All: 6 reference(s)