Neurod1^tm1.1Kan
Targeted Allele Detail

Summary

• Symbol: Neurod1^tm1.1Kan
• Name: neurogenic differentiation 1; targeted mutation 1.1, Klaus-Armin Nave
• MGI ID: MGI:3603335
• Synonyms: NeuroD^loxP
• Gene: Neurod1 Location: Chr2:79282981-79286980 bp, - strand Genetic Position: Chr2, 47.58 cM
• Alliance: Neurod1^tm1.1Kan page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:101098
• Parent Cell Line: E14.1 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: Crossing Neurod1^tm1Kan with mice expressing cre in the germline resulted in the loss of the floxed neo, while the entire coding sequence remained flanked by loxP sites. Western blot of cerebellar protein lysates confirmed that mutant protein levels were comparable with those of wild-type. (J:101098)

Expression

In Mice Carrying this Mutation:

2 RNA-Seq or microarray experiment(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Neurod1 Mutation: 29 strains or lines available

References

• Original: J:101098 Goebbels S, et al., Cre/loxP-mediated inactivation of the bHLH transcription factor gene NeuroD/BETA2. Genesis. 2005 Aug;42(4):247-52
• All: 13 reference(s)