Etv1^{tm1(Ewsr1/Etv4)Arbr}
Targeted Allele Detail

Summary

• Symbol: Etv1^{tm1(Ewsr1/Etv4)Arbr}
• Name: ets variant 1; targeted mutation 1, Silvia Arber
• MGI ID: MGI:3590672
• Synonyms: Er81^EWS-Pea3
• Gene: Etv1 Location: Chr12:38829655-38920484 bp, + strand Genetic Position: Chr12, 17.99 cM
• Alliance: Etv1^{tm1(Ewsr1/Etv4)Arbr} page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:100886
• Parent Cell Line: W9.5/W95 (ES Cell)
• Strain of Origin: 129S1/Sv-Oca2⁺ Tyr⁺ Kitl⁺

Mutation description

• Allele Type: Targeted (Inserted expressed sequence, Null/knockout)
• Mutation: Insertion
• Mutation details: A targeting vector with the fused cDNA encoding Ewsr1/Etv4 was inserted in frame with the start ATG in exon 2. Etv1 expression was abolished in DRG neurons of mutant embryos. (J:100886)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Etv1 Mutation: 44 strains or lines available

References

• Original: J:100886 Hippenmeyer S, et al., A developmental switch in the response of DRG neurons to ETS transcription factor signaling. PLoS Biol. 2005 May;3(5):e159
• All: 1 reference(s)