Dcstamp^tm1Suda
Targeted Allele Detail

Summary

• Symbol: Dcstamp^tm1Suda
• Name: dendrocyte expressed seven transmembrane protein; targeted mutation 1, Toshio Suda
• MGI ID: MGI:3589828
• Synonyms: DC-STAMP^-, Tm7sf4^-
• Gene: Dcstamp Location: Chr15:39609326-39624334 bp, + strand Genetic Position: Chr15, 15.51 cM, cytoband C
• Alliance: Dcstamp^tm1Suda page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:100555
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutation: Insertion
• Mutation details: A targeting vector was designed to insert the enhanced green fluorescent protein sequence and PGK-neo into exon 2 in frame, resulting in the deletion of the second through fifth transmembrane domains. Both full-length and splice variant forms of the transcript were abolished, as demonstrated by RT-PCR analysis. Expression of EGFP was demonstrated in primary osteoclasts of adult tibia. (J:100555)

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Dcstamp Mutation: 28 strains or lines available

References

• Original: J:100555 Yagi M, et al., DC-STAMP is essential for cell-cell fusion in osteoclasts and foreign body giant cells. J Exp Med. 2005 Aug 1;202(3):345-51
• All: 9 reference(s)