Aff4^tm1Nosa
Targeted Allele Detail

Summary

• Symbol: Aff4^tm1Nosa
• Name: AF4/FMR2 family, member 4; targeted mutation 1, Tetsuya Nosaka
• MGI ID: MGI:3586991
• Synonyms: AF5q31^-
• Gene: Aff4 Location: Chr11:53241660-53312657 bp, + strand Genetic Position: Chr11, 31.93 cM
• Alliance: Aff4^tm1Nosa page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:100030
• Parent Cell Line: E14.1 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A neomycin resistance gene replaced exons 2 and 3, encoding the initation codon as well as the N-terminal homology domain and the partial transactivation domain. RT-PCR of mutant MEFs failed to detect transcript. (J:100030)

Expression

In Mice Carrying this Mutation:	39 assay results
In Structures Affected by this Mutation:	6 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Aff4 Mutation: 92 strains or lines available

References

• Original: J:100030 Urano A, et al., Infertility with defective spermiogenesis in mice lacking AF5q31, the target of chromosomal translocation in human infant leukemia. Mol Cell Biol. 2005 Aug;25(15):6834-45
• All: 1 reference(s)