Rdh8^tm1Kpal
Targeted Allele Detail

Summary

• Symbol: Rdh8^tm1Kpal
• Name: retinol dehydrogenase 8; targeted mutation 1, Krzysztof Palczewski
• MGI ID: MGI:3586327
• Synonyms: prRDH^-
• Gene: Rdh8 Location: Chr9:20729799-20737413 bp, + strand Genetic Position: Chr9, 7.64 cM
• Alliance: Rdh8^tm1Kpal page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:99930
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exons 2-4 were replaced with a neomycin resistance gene. Immunoblot of mutants confirmed absence of protein. (J:99930)

Disease models

Expression

In Mice Carrying this Mutation:	1 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 2 strains available Cell Lines: 0 lines available
• Carrying any Rdh8 Mutation: 20 strains or lines available

References

• Original: J:99930 Maeda A, et al., Role of photoreceptor-specific retinol dehydrogenase in the retinoid cycle in vivo. J Biol Chem. 2005 May 13;280(19):18822-32
• All: 50 reference(s)