Cd19^tm1(cre)Thr
Targeted Allele Detail

Summary

• Symbol: Cd19^tm1(cre)Thr
• Name: CD19 antigen; targeted mutation 1, Terence H Rabbitts
• MGI ID: MGI:3584432
• Synonyms: CD19-cre
• Gene: Cd19 Location: Chr7:126007622-126014061 bp, - strand Genetic Position: Chr7, 69.01 cM, cytoband F3-F4
• Alliance: Cd19^tm1(cre)Thr page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:86869
• Parent Cell Line: CCB (ES Cell)
• Strain of Origin: 129S/SvEv-Gpi1^c

Mutation description

• Allele Type: Targeted (Recombinase)
• Mutation: Insertion
• Cd19^tm1(cre)Thr expression driven by 1 gene
  Knock-in expression driven by:
  

  Organism	Driver Gene	Note
  mouse	Cd19 (MGI:88319)

• Mutation details: In frame insertion of a cre recombinase gene into the first coding exon followed by an frt-flanked neomycin cassette. A frameshift mutation was also introduced into exon 5. This allele expresses cre recombinase specifically in B lineage cells throughout development. This allele was made using the same construct used for Cd19^tm1(cre)Cgn, however CCB ES cells were used for targeting. (J:27463)

Recombinase activity

Activity:	Tissue activity of this recombinase allele
Driver:	Cd19 (mouse) Summary of all recombinase alleles driven by Cd19. Alliance mouse Cd19 gene page

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Cd19 Mutation: 56 strains or lines available

References

• Original: J:86869 McCormack MP, et al., The LMO2 T-cell oncogene is activated via chromosomal translocations or retroviral insertion during gene therapy but has no mandatory role in normal T-cell development. Mol Cell Biol. 2003 Dec;23(24):9003-13
• All: 7 reference(s)