Tg(UAS-Smo*W539L)1Amc
Transgene Detail

Summary

• Symbol: Tg(UAS-Smo*W539L)1Amc
• Name: transgene insertion 1, Andrew P McMahon
• MGI ID: MGI:3584023
• Synonyms: UAS-Smo*
• Transgene: Tg(UAS-Smo*W539L)1Amc Location: unknown
• Alliance: Tg(UAS-Smo*W539L)1Amc page

Transgene origin

• Strain of Origin: Not Applicable

Transgene description

• Transgene Type: Transgenic (Inserted expressed sequence)
• Mutation: Insertion
• Tg(UAS-Smo*W539L)1Amc expresses 1 gene
  Transgene expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  rat

  Smo (25273)

  Smo	(MGI:108075)

  Transgene codes for a protein with a tryptophan to leucine mutation.

• Mutation details: This transgene contains five upstream activating sequence (UAS) elements, a Wnt1 promoter, the rat Smo cDNA containing a W539L mutation, the human placental alkaline phosphatase cDNA under the control of an internal ribosomal entry site, lacZ, and a poly A signal from the murine Wnt1 gene. UAS elements drive the expression of the mutated ligand-independent activated rat Smo gene. Expression of this transgene is dependent on GAL4 expression. (J:73071)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:73071 Long F, et al., Genetic manipulation of hedgehog signaling in the endochondral skeleton reveals a direct role in the regulation of chondrocyte proliferation. Development. 2001 Dec;128(24):5099-108
• All: 1 reference(s)