Epha7^tm1Ud
Targeted Allele Detail

Summary

• Symbol: Epha7^tm1Ud
• Name: Eph receptor A7; targeted mutation 1, Uwe Drescher
• MGI ID: MGI:3583808
• Synonyms: Epha7^-
• Gene: Epha7 Location: Chr4:28813131-28967499 bp, + strand Genetic Position: Chr4, 12.42 cM
• Alliance: Epha7^tm1Ud page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:99629
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: Upstream sequence and exon 1, which contains the start coding and signal peptide, was replaced by a loxP-flanked neomycin selection cassette, which subsequently was removed via cre-mediated recombination. Sucessful ablation of the gene was confirmed by RT-PCR, in situ hybridization and Western blot analyses. (J:99629)

Expression

In Mice Carrying this Mutation:

4 assay results

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Epha7 Mutation: 57 strains or lines available

References

• Original: J:99629 Rashid T, et al., Opposing Gradients of Ephrin-As and EphA7 in the Superior Colliculus Are Essential for Topographic Mapping in the Mammalian Visual System. Neuron. 2005 Jul 7;47(1):57-69
• All: 10 reference(s)