Ptk2^tm1.2Guan
Targeted Allele Detail

Summary

• Symbol: Ptk2^tm1.2Guan
• Name: PTK2 protein tyrosine kinase 2; targeted mutation 1.2, Jun-Lin Guan
• MGI ID: MGI:3583807
• Synonyms: FAK^delta
• Gene: Ptk2 Location: Chr15:73076951-73295129 bp, - strand Genetic Position: Chr15, 33.94 cM
• Alliance: Ptk2^tm1.2Guan page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:99637
• Parent Cell Line: E14.1 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: Exon 3 was deleted via cre-mediated excision, resulting in a frame-shift mutation and the direct splicing of exon 2 to exon 4, and the production of a truncated protein of approximately 70 amino acids. Western blot of E8.5 lysates confirmed absence of protein in embryos. (J:99637)

Expression

In Structures Affected by this Mutation:

8 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Ptk2 Mutation: 90 strains or lines available

References

• Original: J:99637 Shen TL, et al., Conditional knockout of focal adhesion kinase in endothelial cells reveals its role in angiogenesis and vascular development in late embryogenesis. J Cell Biol. 2005 Jun 20;169(6):941-52
• All: 2 reference(s)