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Reb1129P2/OlaHsd
QTL Variant Detail
Summary
QTL variant: Reb1129P2/OlaHsd
Name: repetitive behavior 1; 129P2/OlaHsd
MGI ID: MGI:3582688
QTL: Reb1  Location: Chr1:91468266-100413667 bp  Genetic Position: Chr1, Syntenic
Variant
origin
Strain of Specimen:  129P2/OlaHsd
Variant
description
Allele Type:    QTL
Mutation:    Undefined
 
Mutation detailsMice homozygous for this allele exhibit less repetitive activity, as shown by more frequent repetitive beam breaks in an open-field activity box, than do mice homozygous for the C57BL/6J-derived allele.
Inheritance:    Codominant
Notes
Mice heterozygous at this locus, i.e., having one C57BL/6J allele and one 129P2/OlaHsd allele, exhibit repetitive activity levels intermediate between those of animals homozygous for either parental allele.

Mapping and Phenotype information for this QTL, its variants and associated markers

J:105315

Subcongenic lines derived from B6.129P2-Il10tm1Cgn/J were used to map behavioral QTL Emo4 (emotionality 4) and Reb1 (repetitive beam breaks 1) to 2 intervals on mouse Chromosome 1. Background strain C57BL/6J exhibits higher scores on repetitive beam breaks and increased open field activity compared to B6.129P2-Il10tm1Cgn/J suggesting that one or more genes responsible for the modified behavioral phenotypes lie within the 129P2-derived Il10tm1Cgn locus.

Emo4 mapped to a 17.8 Mb interval on mouse Chromosome 1 between Erbb4 (68.4 Mb) and B3gnt7 (86.2 Mb). Emo4 appears distinct from Emo1 and Emo3 as both previously identified loci map at least 30 cM away. Gene expression microarray analysis identified a potential candidate gene named Wdfy1, which maps to the Emo4 QTL interval. Wdfy1 exhibits significantly increased expression in a B6.129P2-Il10tm1Cgn/J subcongenic line R5 compared to C57BL/6J.

Reb1 mapped to an 8.6 Mb interval between Asb1 (91.4 Mb) and NM_172851 (100 Mb). This locus was confirmedby linkage analysis using 750 (C57BL/6J x 129S1/SvImJ)F1 x C57BL/6J backcross animals. The Reb1 interval corresponds to a region on human Chromosome 2q36.2-36.3 that shows linkage to autism susceptibility. Gene expression microarray analysis identified 2potential candidate genes named Pam (97.6 Mb) and Stk25 (93.4 Mb). Both genes have been implicated in brain function.

References
Original:  J:105315 de Ledesma AM, et al., Two new behavioral QTLs, Emo4 and Reb1, map to mouse Chromosome 1: Congenic strains and candidate gene identification studies. Mamm Genome. 2006 Feb;17(2):111-8
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
07/02/2024
MGI 6.13
The Jackson Laboratory