Trbv15^tm1Krg
Targeted Allele Detail

Summary

• Symbol: Trbv15^tm1Krg
• Name: T cell receptor beta, variable 15; targeted mutation 1, Michael S Krangel
• MGI ID: MGI:3581023
• Synonyms: EalphaKI
• Gene: Trbv15 Location: Chr6:41118145-41118592 bp, + strand Genetic Position: Chr6, 19.23 cM
• Alliance: Trbv15^tm1Krg page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:95669
• Parent Cell Line: EF1 (ES Cell)
• Strain of Origin: 129S/SvEv x C57BL/6

Mutation description

• Allele Type: Targeted
• Mutation: Insertion
• Mutation details: The Tcra enhancer (Ealpha) was inserted approximately 0.5 kb downstream of Tcrb-V12. Surface staining of thymocytes and splenocytes demonstrated an increase in usage of Tcrb-V12 two- to three-fold higher than in wild-type mice. (J:95669)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Trbv15 Mutation: 10 strains or lines available

References

• Original: J:95669 Jackson A, et al., Regulation of T cell receptor beta allelic exclusion at a level beyond accessibility. Nat Immunol. 2005 Feb;6(2):189-97
• All: 2 reference(s)