Pyy^tm1Able
Targeted Allele Detail

Summary

• Symbol: Pyy^tm1Able
• Name: peptide YY; targeted mutation 1, Andrew B Leiter
• MGI ID: MGI:3580424
• Synonyms: Pyy^-
• Gene: Pyy Location: Chr11:101997502-101998658 bp, - strand Genetic Position: Chr11, 65.48 cM
• Alliance: Pyy^tm1Able page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:98886
• Parent Cell Line: TL1/TL-1 (ES Cell)
• Strain of Origin: 129S6/SvEvTac

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutation: Insertion
• Mutation details: Exons 2-4, spanning amino acids 7-93, were replaced with an in-frame lacZ and a floxed PGK-neo selection cassette. The neo was removed via cre-mediated recombination. RT-PCR confirmed absence of transcript in colon samples from mutant mice. Betagalactosidase activity was detected in the colon and around the periphery of the islets. (J:98886)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Pyy Mutation: 9 strains or lines available

References

• Original: J:98886 Schonhoff S, et al., Energy homeostasis and gastrointestinal endocrine differentiation do not require the anorectic hormone peptide YY. Mol Cell Biol. 2005 May;25(10):4189-99
• All: 2 reference(s)