Pcp2^tm1Jim
Targeted Allele Detail

Summary

• Symbol: Pcp2^tm1Jim
• Name: Purkinje cell protein 2 (L7); targeted mutation 1, James I Morgan
• MGI ID: MGI:3579785
• Synonyms: L7/Pcp2^-
• Gene: Pcp2 Location: Chr8:3673371-3675545 bp, - strand Genetic Position: Chr8, 1.92 cM
• Alliance: Pcp2^tm1Jim page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:40442
• Parent Cell Line: W9.5/W95 (ES Cell)
• Strain of Origin: 129S1/Sv-Oca2⁺ Tyr⁺ Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Insertion
• Mutation details: A neo cassette was inserted into the Eco47III site in the second exon. Northern blot and immunohistochemistry confirmed the loss of the Pcp2 transcripts and protein, respectively. (J:40442)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Pcp2 Mutation: 36 strains or lines available

References

• Original: J:40442 Vassileva G, et al., Absence of neuroanatomical and behavioral deficits in L7/pcp-2-null mice. Brain Res Mol Brain Res. 1997 Jun;46(1-2):333-7
• All: 2 reference(s)