Itgax^tm1Bll
Targeted Allele Detail

Summary

• Symbol: Itgax^tm1Bll
• Name: integrin alpha X; targeted mutation 1, Christie M Ballantyne
• MGI ID: MGI:3579560
• Synonyms: Cd11c^-, CR4^-
• Gene: Itgax Location: Chr7:127728719-127749829 bp, + strand Genetic Position: Chr7, 69.98 cM
• Alliance: Itgax^tm1Bll page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:90954
• Parent Cell Line: AB2.1 (ES Cell)
• Strain of Origin: 129S7/SvEvBrd-Hprt1^b-m2

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Not Specified
• Exons 1 through 3 were replaced with a neo cassette. (J:166427)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Itgax Mutation: 73 strains or lines available

References

• Original: J:90954 Wu H, et al., Deficiency of CD11b or CD11d results in reduced staphylococcal enterotoxin-induced T cell response and T cell phenotypic changes. J Immunol. 2004 Jul 1;173(1):297-306
• All: 18 reference(s)