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Thy1a
Allele Detail
Summary
Symbol: Thy1a
Name: thymus cell antigen 1, theta; a variant
MGI ID: MGI:3579311
Synonyms: thetaAKR, theta-AKR, Thy-1.1, Thy1.1, Thy1a
Gene: Thy1  Location: Chr9:43954681-43959876 bp, + strand  Genetic Position: Chr9, 24.52 cM
Alliance: Thy1a page
Mutation
origin
Strain of Origin:  Not Applicable
Mutation
description
Allele Type:    Not Applicable
Mutation:    Not Applicable
 
Mutation detailsThe allele Thy1a determines an antigenic specificity, Thy-1.1, found in the AKR and RF strains.
Tumor Data
List all tumor models in MMHCdb carrying Thy1a
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 38 strains available      Cell Lines: 0 lines available
Carrying any Thy1 Mutation:  201 strains or lines available
Notes

The Thy1 locus determines a surface antigen present on cells of the thymus, a number of mouse leukemias, brain, and in lesser amounts on lymph node and spleen cells. The allele Thy1a determines an antigenic specificity, Thy-1.1, found in the AKR and RF strains; the allele Thy1b determines an antigenic specificity, Thy-1.2, found in the C3HeB/Fe and many other strains (J:5243, J:5012, J:4469). The Thy1 antigen is probably present on all T lymphocytes and absent from all B lymphocytes, and it thus serves as a valuable T-cell marker (J:5243). It is very widely used in experiments designed to determine the distribution and function of T-cells. Thy1 specifies a T-cell surface glycoprotein, T25, with a molecular weight of 25 kDa (J:5707). The protein appears to be anchored in the cell membrane by a lipid that is either phosphotidylinositol or closely related to it (J:12016). Thy1 may function in the cell membrane as a signal transduction molecule (J:8333). The Thy1 locus, or possibly a gene closely linked to it, controls quantitative expression of a protein that is the same size as Thy1 and is expressed on thymus and brain but not on lymph node and spleen cells (J:7900).

References
Original:  J:24839 REIF AE, et al., THE AKR THYMIC ANTIGEN AND ITS DISTRIBUTION IN LEUKEMIAS AND NERVOUS TISSUES. J Exp Med. 1964 Sep 1;120:413-33
All:  69 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
01/17/2023
MGI 6.22
The Jackson Laboratory