Il18rap^tm1Yeh
Targeted Allele Detail

Summary

• Symbol: Il18rap^tm1Yeh
• Name: interleukin 18 receptor accessory protein; targeted mutation 1, Wen-Chen Yeh
• MGI ID: MGI:3579137
• Synonyms: AcPL^-
• Gene: Il18rap Location: Chr1:40554522-40590865 bp, + strand Genetic Position: Chr1, 19.37 cM
• Alliance: Il18rap^tm1Yeh page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:98417
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A targeting vector was designed to replace exon 2, which encodes the transmembrane region, and exon 3, with a neomycin resistance gene. RT-PCR failed to detect transcript in mutant MEFs. (J:98417)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Il18rap Mutation: 57 strains or lines available

References

• Original: J:98417 Cheung H, et al., Accessory protein-like is essential for IL-18-mediated signaling. J Immunol. 2005 May 1;174(9):5351-7
• All: 1 reference(s)