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Bntq11DBA/2J
QTL Variant Detail
Summary
QTL variant: Bntq11DBA/2J
Name: bone traits QTL 11; DBA/2J
MGI ID: MGI:3578965
QTL: Bntq11  Location: unknown  Genetic Position: Chr9, Syntenic
Variant
origin
Strain of Specimen:  DBA/2J
Variant
description
Allele Type:    QTL
Notes

Mapping and Phenotype information for this QTL, its variants and associated markers

J:95898

Linkage analysis was performed on 400 (C57BL/6J x DBA/2J)F2 animals and 26 BXD RI strains to identify QTLs associated with skeletal phenotypes. A panel of 672 microsatellite markers was used in the genome scan for the BXD RI group and 96 microsatellite markers at a resolution of 15-20 cM were used in the genome scan for the F2 group. Loci identified with significant linkage in the F2 group and confirmed in the BXD RI group are reported here.

An interval on mouse Chromosome 9 between 7 cM - 23 cM showedlinkage to femur modulus and stress, shear ultimate load, and tibia cortical area. This locus is named Bntq10 (bone traits QTL 10). Maximum linkage occurs at 7 cM for tibia cortical area (LOD=3.5). A potential candidate gene for Bntq10 is Acp5 at 6 cM. Asecond interval between 36 cM - 65 cM showed linkage to tibia stiffness and tibia ultimate load (LOD=3.6). This locus is named Bntq11. Maximum linkage occurs at 65 cM for tibia ultimate load (LOD=3.6). Previously identified bone QTLs mapping near Bntq11 are Bmd10 (48 cM), Tbbmd4 (49 cM), and Vtbt8 (48 cM).

References
Original:  J:95898 Lang DH, et al., Quantitative trait loci analysis of structural and material skeletal phenotypes in C57BL/6J and DBA/2 second-generation and recombinant inbred mice. J Bone Miner Res. 2005 Jan;20(1):88-99
All:  1 reference(s)

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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
03/19/2024
MGI 6.23
The Jackson Laboratory