Pcp2^tm1(cre)Nobs
Targeted Allele Detail

Summary

• Symbol: Pcp2^tm1(cre)Nobs
• Name: Purkinje cell protein 2 (L7); targeted mutation 1, Noboru Suzuki
• MGI ID: MGI:3578623
• Synonyms: L7-Cre-KI^-
• Gene: Pcp2 Location: Chr8:3673371-3675545 bp, - strand Genetic Position: Chr8, 1.92 cM
• Alliance: Pcp2^tm1(cre)Nobs page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:98285
• Parent Cell Line: RW-4 (ES Cell)
• Strain of Origin: 129X1/SvJ

Mutation description

• Allele Type: Targeted (Recombinase)
• Mutation: Insertion
• Pcp2^tm1(cre)Nobs expression driven by 1 gene
  Knock-in expression driven by:
  

  Organism	Driver Gene	Note
  mouse	Pcp2 (MGI:97508)

• Mutation details: Cre recombinase cDNA and a neomycin resistance gene were inserted into the second exon to be expressed by the endogenous locus. Histological staining of mutants demonstrated cre was expressed exclusively in Purkinje cells of cerebellum and in bipolar neurons of retina. (J:98285)

Recombinase activity

Activity:	Tissue activity of this recombinase allele
Driver:	Pcp2 (mouse) Summary of all recombinase alleles driven by Pcp2. Comparative matrix view of recombinase activities Alliance mouse Pcp2 gene page

Expression

In Mice Carrying this Mutation:

3 assay results

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Pcp2 Mutation: 36 strains or lines available

References

• Original: J:98285 Saito H, et al., L7/Pcp-2-specific expression of Cre recombinase using knock-in approach. Biochem Biophys Res Commun. 2005 Jun 17;331(4):1216-21
• All: 12 reference(s)