Trp53^tm1.1Att
Targeted Allele Detail

Summary

• Symbol: Trp53^tm1.1Att
• Name: transformation related protein 53; targeted mutation 1.1, Laura D Attardi
• MGI ID: MGI:3575501
• Synonyms: Trp53^QS
• Gene: Trp53 Location: Chr11:69471185-69482699 bp, + strand Genetic Position: Chr11, 42.83 cM, cytoband B2-C
• Alliance: Trp53^tm1.1Att page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:96433
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted
• Mutation: Intragenic deletion
• Mutation details: The loxP-Stop-loxP cassette was removed by Cre-mediated recombination leaving a single loxP site upstream of exon 2 and allowing expression of the mutant protein containing p.L25Q and p.W26S substitutions in exon 2 (TTATGG>CAATCG). (J:96433)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Trp53 Mutation: 232 strains or lines available

References

• Original: J:96433 Johnson TM, et al., The p53QS transactivation-deficient mutant shows stress-specific apoptotic activity and induces embryonic lethality. Nat Genet. 2005 Feb;37(2):145-52
• All: 3 reference(s)