Eamcd2^A/WySn
QTL Variant Detail

Summary

• QTL variant: Eamcd2^A/WySn
• Name: experimental autoimmune myocarditis 2; A/WySn
• MGI ID: MGI:3574856
• QTL: Eamcd2 Location: Chr6:146953954-146954059 bp Genetic Position: Chr6, cM position of peak correlated region/allele: 77.7 cM
• QTL Note: genome coordinates based on the marker associated with the peak LOD score

Variant origin

• Strain of Specimen: A/WySn

Variant description

• Allele Type: QTL
• Mutation: Undefined
• Mutation details: This allele confers susceptibility to experimental autoimmune myocarditis in male animals compared to C57BL/10J. (J:96562)
• Inheritance: Recessive

Notes

Mapping and Phenotype information for this QTL, its variants and associated markers

J:96562

Linkage analysis was performed on a population of (B10.S-H2^s/J x A.SW-H2^s/J)F2 animals to identify QTLs associated with experimental autoimmune myocarditis. Parental strain A.SW-H2^s/J is susceptible to experimental autoimmune myocarditis after immunization with mouse cardiac myosin, which is characterized by the production of cardiac-specfic autoantibodies and diffuse mononuclear infiltratation. Parental strain B10.S-H2^s/J is resistant to experimentally induced myocarditis and exhibits minimal inflammation. 81 polymorphic markers at an average spacing of 20 cM were used in the genome scan.

144 phenotypically extreme F2 animals were used for the initial genome scan. Linkage was detected on mouse Chromosome 1, 4, and 6. After genotyping remainingF2 progeny (total n=296) significant linkage was confirmed for mouse Chromosome 6. This locus is named Eamcd2 (experimental autoimmune myocarditis 2). Eamcd2 is a male specific locus and maps to 74.3 cM (LOD=5.7 at D6Mit373). The 1.5 LOD support intervalspans 9 cM around the peak. A/J-derived alleles from A.SW-H2^s confer increased susceptibility to autoimmune myocarditis in male animals at Eamcd2.

Previously identified diabetes QTL Idd6 (73 cM) overlaps with Eamcd2. Idd6 was identified in diabetes susceptible strain NOD. Idd6 also exhibits a greater effect in male animals similar to Eamcd2.

Highly suggestive linkage mapped to mouse Chromosome 1 (LOD=3.26) but this locus warrants further analysis and mapping. This region of chromosome 1 overlaps with a previously identified diabetes QTL named Idd5 (40 cM).

References

• Original: J:96562 Guler ML, et al., Two autoimmune diabetes Loci influencing T cell apoptosis control susceptibility to experimental autoimmune myocarditis. J Immunol. 2005 Feb 15;174(4):2167-73
• All: 1 reference(s)