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Cdh17tm1Ohn
Targeted Allele Detail
Summary
Symbol: Cdh17tm1Ohn
Name: cadherin 17; targeted mutation 1, Kazuo Ohnishi
MGI ID: MGI:3573870
Synonyms: BILL-cadherin-
Gene: Cdh17  Location: Chr4:11758157-11817905 bp, + strand  Genetic Position: Chr4, 5.35 cM, cytoband A2
Alliance: Cdh17tm1Ohn page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:96738
Parent Cell Line:  E14.1 (ES Cell)
Strain of Origin:  129P2/OlaHsd
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsExons 16-18, which encode the transmembrane and cytoplasmic domain, were replaced with a neomycin resistance cassette. Surface labeling and subsequent immunoprecipitation demonstrated the complete absence of protein on surface of B lineage cells. (J:96738)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 3 anatomical structure(s)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Cdh17 Mutation:  45 strains or lines available
References
Original:  J:96738 Ohnishi K, et al., Lymphocyte-expressed BILL-cadherin/cadherin-17 contributes to the development of B cells at two stages. Eur J Immunol. 2005 Mar;35(3):957-63
All:  2 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
05/07/2024
MGI 6.23
The Jackson Laboratory