Gphb5^tm1Lmac
Targeted Allele Detail

Summary

• Symbol: Gphb5^tm1Lmac
• Name: glycoprotein hormone beta 5; targeted mutation 1, Lynn E Macdonald
• MGI ID: MGI:3573779
• Synonyms: OGH^-
• Gene: Gphb5 Location: Chr12:75458496-75463555 bp, - strand Genetic Position: Chr12, 32.71 cM
• Alliance: Gphb5^tm1Lmac page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:96633
• Parent Cell Line: CJ7 (ES Cell)
• Strain of Origin: 129S1/Sv-Oca2⁺ Tyr⁺ Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Velocigene technology was used to delete exons 1 and 2, containing the entire coding region, and replace them with a lacZ reporter and neomycin resistance gene. (J:96633)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Gphb5 Mutation: 8 strains or lines available

References

• Original: J:96633 Macdonald LE, et al., Resistance to diet-induced obesity in mice globally overexpressing OGH/GPB5. Proc Natl Acad Sci U S A. 2005 Feb 15;102(7):2496-501
• All: 1 reference(s)