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Transgene Detail
Symbol: Tg(Rr28-Igf2)1bDdp
Name: transgene insertion 1b, Dimitrina D Pravtcheva
MGI ID: MGI:3573688
Synonyms: 1B, pmH19eIgfMlu 1B
Transgene: Tg(Rr28-Igf2)1bDdp  Location: unknown  
Alliance: Tg(Rr28-Igf2)1bDdp page
Strain of Origin:  FVB/N
Transgene Type:    Transgenic (Inserted expressed sequence)
Mutation:    Insertion
Tg(Rr28-Igf2)1bDdp expresses 1 gene
Mutation detailsThis transgene contains a 17 kb genomic fragment containing the entire coding region of a partially methylated mouse Igf2 under control of its own promoter. A small 5' fragment of the noncoding region of exon 1 was left out of this construct. The MluI restriction site at the 3' end of the nontranslated portion of exon 6 was abolished to distinguish the transgene from the endogenous Igf2 gene. A 7 kb genomic fragment containing the mouse Igf2/H19 enhancer sequences (Rr28) from downstream of H19 was cloned upstream of the Igf2 gene. RT-PCR analysis showed transgene expression equal to or slightly higher than the endogenous Igf2 protein in the liver, kidney, lung, heart, and mammary tissue. (J:90325)
Tumor Data
List all tumor models in MMHCdb carrying Tg(Rr28-Igf2)1bDdp
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Original:  J:90325 Wise TL, et al., Perinatal lethality in H19 enhancers-Igf2 transgenic mice. Mol Reprod Dev. 1997 Oct;48(2):194-207
All:  2 reference(s)

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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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MGI 6.24
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