Stx1b^{Gt(OST68841)Lex}
Gene trapped Allele Detail

Summary

• Symbol: Stx1b^{Gt(OST68841)Lex}
• Name: syntaxin 1B; gene trap OST68841, Lexicon Genetics
• MGI ID: MGI:3531159
• Synonyms: Stx1b^{Gt(Betageo)673Lex}
• Gene: Stx1b Location: Chr7:127403072-127423703 bp, - strand Genetic Position: Chr7, 69.75 cM
• Alliance: Stx1b^{Gt(OST68841)Lex} page

Mutation origin

• Mutant Cell Line: OST68841
• Germline Transmission: Earliest citation of germline transmission: J:94338
• Parent Cell Line: Lex-1 (ES Cell)
• Strain of Origin: 129S5/SvEvBrd
• Project Collection: Lexicon

Mutation description

• Allele Type: Gene trapped
• Mutation: Insertion of gene trap vector
• Mutation details: An insertion of the Omnibank Vector VICTR24 in the first exon of the gene led to the splicing of the endogenous upstream exons into the gene trap cassette. This resulted in the production of a fusion transcript that contained the beta-galactosidase gene. Western blot analyses demonstrated absence of encoded protein in homozygous mutant mice. (J:264021)
• Sequence Tags: Sequence tag details (1 tag)

  Tag ID	GenBank ID	Method	Tag Location (trapped strand)*	Select
  OST68841	CG514858 ; (MGI Seq Detail)	3' RACE	Chr7:127410152-127414562 bp (-)
  * GRCm39; (strand of gene trap mutagenesis)

• Genome Context: Genome Browser view of this mutation;

  3 gene trap insertions have trapped this gene; View all gene trap sequence tags in this region

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Stx1b Mutation: 19 strains or lines available

References

• Original: J:94338 NIH Mouse Knockout Inventory, Information obtained from the NIH Mouse Knockout Inventory. MGI Direct Data Submission. 2004
• All: 4 reference(s)