Rras^{Gt(OST24882)Lex}
Gene trapped Allele Detail

Summary

• Symbol: Rras^{Gt(OST24882)Lex}
• Name: related RAS viral (r-ras) oncogene; gene trap OST24882, Lexicon Genetics
• MGI ID: MGI:3530792
• Synonyms: Rras^{Gt(IRESBetageo)552Lex}, R-Ras-KO
• Gene: Rras Location: Chr7:44667385-44671071 bp, + strand Genetic Position: Chr7, 29.08 cM
• Alliance: Rras^{Gt(OST24882)Lex} page

Mutation origin

• Mutant Cell Line: OST24882
• Germline Transmission: Earliest citation of germline transmission: J:104130
• Parent Cell Line: Lex-1 (ES Cell)
• Strain of Origin: 129S5/SvEvBrd
• Project Collection: Lexicon

Mutation description

• Allele Type: Gene trapped (Null/knockout)
• Mutation: Insertion of gene trap vector
• Mutation details: An insertion of the gene-trap vector VICTR20 between exons 4 and 5 of the gene disrupted expression as determined by RT-PCR, real-time RT-PCR and R-Ras-specific immunoblotting of tissue extracts as well as immunohistochemistry of tissue sections. (J:46940)
• Sequence Tags: Sequence tag details (1 tag)

  Tag ID	GenBank ID	Method	Tag Location (trapped strand)*	Select
  OST24882	CG488807 ; (MGI Seq Detail)	3' RACE	Chr7:44670508-44670963 bp (+)
  * GRCm39; (strand of gene trap mutagenesis)

• Genome Context: Genome Browser view of this mutation;

  7 gene trap insertions have trapped this gene; View all gene trap sequence tags in this region

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 2 strains available Cell Lines: 0 lines available
• Carrying any Rras Mutation: 19 strains or lines available

References

• Original: J:104130 Komatsu M, et al., R-Ras is a global regulator of vascular regeneration that suppresses intimal hyperplasia and tumor angiogenesis. Nat Med. 2005 Dec;11(12):1346-1350
• All: 15 reference(s)